Research & Evidence
Floater-focused research. Broader daily eye nutrition.
Explore research on eye floaters, retinal carotenoids, macular pigment, and tear-film measures related to dry eye and screen use. See the evidence ↓Our approach
Built around floater research.
Broadened for daily eye nutrition.
Haro Clear combines five nutrient categories represented in
FLIES
Floater Intervention Study (FLIES): a 2021 trial of a five-nutrient supplement for adults with symptomatic vitreous floaters.
, 900 mg of fruit enzymes per daily serving, and the retinal carotenoids lutein and zeaxanthin.
Retinal carotenoids
8mglutein + zeaxanthin
Carotenoids found in the retina and lens, included in every daily Haro Clear serving.
Daily enzyme serving
900mgbromelain + papain
The largest ingredients in the formula by weight.
FLIES Floater Intervention Study (FLIES): a 2021 trial of a five-nutrient supplement for adults with symptomatic vitreous floaters. connection
Five targeted micronutrients.
Broader eye nutrition
9complementary ingredients
Enzymes, carotenoids and targeted micronutrients in one routine.Lutein and zeaxanthin research: macular pigment and screen-use studies
Lutein and zeaxanthin are carotenoids found in the retina and lens. In the macula, the central area used for detailed vision, they contribute to macular pigment—a natural filter that absorbs blue light. Researchers study how these nutrients relate to visual performance and eye comfort.
What was tested?
2025 screen-use trial: Adults using screens at least six hours daily received 10 mg lutein plus 2 mg zeaxanthin isomers or placebo each day. The trial was randomized and double-blind.
2014 visual-performance trial: A randomized, double-blind trial enrolled 115 young, healthy adults. Participants received 10 mg lutein plus 2 mg zeaxanthin daily or placebo for one year.
What did researchers find?
2025 screen-use trial: Compared with placebo, the supplement group improved on tear-production, tear-film stability and bright-light recovery tests. Self-reported symptoms and contrast sensitivity showed no significant between-group improvement.
2014 visual-performance trial: Macular pigment density, recovery after bright light and a color-contrast test improved versus placebo. The glare-disability test did not show a significant treatment benefit.
How to read the findings
Measured improvements and everyday symptom relief are different outcomes. Results relate to the formula, dose and population studied; Haro Clear uses a different nine-ingredient formula with a two-capsule daily serving. Screen-use outcomes measured in this trial included tear-film function and visual recovery; protection from retinal damage was not assessed.
Funding and disclosures
The 2025 trial was funded by Bio-gen Extracts Pvt. Ltd., which supplied the study capsules. The 2014 trial was supported by DSM Nutritional Products Ltd. and Kemin Foods L.C. Both papers disclose commercial relationships.
How is macular pigment measured?
Macular pigment optical density measures how strongly that pigment absorbs light. It is distinct from a person’s symptom score.
- Read the 2025 screen-use studyLopresti & Smith (2025) · Frontiers in Nutrition · 12:1522302 · DOI: 10.3389/fnut.2025.1522302
- Read the 2014 macular pigment studyHammond et al. (2014) · Investigative Ophthalmology & Visual Science · 55(12):8583–8589 · DOI: 10.1167/iovs.14-15573
Fruit enzyme study A 2022 trial of bromelain, papain and ficin in adults with vitreous floaters. : what it tested
Two daily capsules of Haro Clear provide 600 mg bromelain and 300 mg papain. Together, these fruit-derived enzymes contribute 900 mg and are the formula’s largest ingredients by weight.
Published visual evidence
Compare the study’s before-and-after figures.
Case examples reproduced from the published 2022 mixed-fruit-enzyme study.
Before: A 55-year-old woman had one eye floater visible on a B-scan at the start of the study.
After three months: The paper reports that the floater was significantly reduced on the follow-up B-scan after she received the mixed fruit enzyme supplement tested in the study.
Before: A 58-year-old man with diabetes had a dark-red cloud over the retina caused by bleeding inside the eye.
After three months: The paper reports that the clouding decreased and his vision improved from 20/200 to 20/40 after he received the mixed fruit enzyme supplement tested in the study.
What was tested?
The 2022 study included 160 participants with spontaneous vitreous opacities and 64 with hemorrhage-related opacities. These are different clinical situations; the before-and-after examples should be read in that context. Over three months, participants received a vitamin C comparator or one, two or three daily capsules of a combination containing bromelain, papain and ficin. The researchers reported improvements with the combination tested.
How to read the findings
Haro Clear centers its fruit-enzyme component on 600 mg bromelain and 300 mg papain, paired with targeted micronutrients, lutein and zeaxanthin in a nine-ingredient formula.
This trial tested bromelain, papain and ficin together. Haro Clear does not contain ficin and was not tested in this trial; these findings do not establish equivalent results for Haro Clear.
- Read the complete study Ma et al. (2022) · Journal of Clinical Medicine · 11(22):6710 · DOI: 10.3390/jcm11226710
The FLIES Floater Intervention Study (FLIES): a 2021 trial of a five-nutrient supplement for adults with symptomatic vitreous floaters. trial: targeted micronutrients for floater discomfort
The 2021 Floater Intervention Study (FLIES) was a double-blind, randomized, placebo-controlled trial. It assigned 61 adults with symptomatic eye floaters to VitroCap N or placebo for 6 months; 56 completed the trial. The active group reported less floater discomfort and had a reduction in measured vitreous opacity area; the placebo group showed no significant change in these measures. One measure of contrast sensitivity also improved in the active group.
Haro Clear includes the five nutrient categories represented in FLIES, alongside bromelain, papain, lutein and zeaxanthin for broader daily eye nutrition. FLIES tested VitroCap N, not Haro Clear; shared nutrient categories do not establish equivalent results.
What was tested?
One daily capsule of VitroCap N supplied 125 mg L-lysine, 40 mg vitamin C, 26.3 mg grape seed extract, 5 mg zinc and 100 mg citrus-derived extract. The trial evaluated this combination as a whole.
How to read the findings
The results relate to the tested formula and study population. Haro Clear uses its own ingredient forms, amounts and two-capsule daily serving. Researchers assessed both reported floater discomfort and measured opacity area; not every participant contributed to every endpoint. The trial was small and conducted at one center. Its symptom questionnaire was not independently validated, and one masked investigator manually outlined the opacity images before software measured their area. The paper reports commercial funding and related interests.
- Read the complete study Ankamah et al. (2021) · Translational Vision Science & Technology · 10(12):19 · DOI: 10.1167/tvst.10.12.19
Looking for Haro Clear vs. VitreousHealth? View the separate formula comparison →
AREDS2 study: supplements for age-related macular degeneration
The Age-Related Eye Disease Study 2 (AREDS2) examined changes to a high-dose supplement formula for people at risk of advanced age-related macular degeneration (AMD).
- Lutein
- Zeaxanthin
- Vitamin C
- Zinc
Haro Clear uses different amounts and combines these with five ingredients that are not part of the standard AREDS2 formula.
What was tested?
The NEI-funded trial enrolled 4,203 adults with intermediate AMD in both eyes, or intermediate AMD in one eye and advanced AMD in the other. Researchers tested adding lutein and zeaxanthin or omega-3 fatty acids, removing beta-carotene, and lowering zinc in the original AREDS formula. They measured progression to advanced AMD over about five years.
How to read the findings
In the main analysis, adding lutein and zeaxanthin or omega-3s did not significantly reduce progression to advanced AMD. Further analyses supported using lutein and zeaxanthin in place of beta-carotene. AREDS/AREDS2 evidence supports specific supplement formulas for certain stages of AMD.
Ask your eye-care professional whether an AREDS2 formula is appropriate for your AMD stage, and discuss other medicines and supplements you take.
What is in the standard AREDS2 formula?
| Nutrient | Daily amount |
|---|---|
| Vitamin C | 500 mg |
| Vitamin E | 400 IU |
| Zinc | 80 mg |
| Copper | 2 mg |
| Lutein | 10 mg |
| Zeaxanthin | 2 mg |
The standard formula contains no beta-carotene. AREDS2 also studied 25 mg zinc. See the NEI formula guidance.
Does AREDS2 help with eye floaters?
AREDS2 studied AMD progression, not eye-floater symptoms. Its findings do not establish that AREDS2 supplements treat floaters.
Is Haro Clear an AREDS2 supplement?
No. Haro Clear has different amounts and does not contain vitamin E or copper. View Haro Clear’s ingredients and daily amounts.
Explore macular degeneration research
- National Eye Institute: AREDS2 formula and clinical guidance
- Read the complete study Age-Related Eye Disease Study 2 Research Group (2013) · JAMA · 309(19):2005–2015 · DOI: 10.1001/jama.2013.4997
Haro Clear formula: nine ingredients and daily amounts
Haro Clear combines micronutrients, fruit enzymes and retinal carotenoids in a two-capsule daily serving. The overview below shows all nine ingredients and their daily amounts.
- Vitamin C
- 40 mg
- Bromelain
- 600 mg
- L-lysine
- 130 mg
- Papain
- 300 mg
- Hesperidin
- 100 mg
- Grape seed extract
- 30 mg
- Zinc
- 5 mg
- Lutein
- 4 mg
- Zeaxanthin
- 4 mg
How the formula relates to the research
These ingredient groups connect to the studies explained in this research hub. Each study used its own formula, doses and participant group; the findings should be read in that context. Haro Clear brings these nine ingredients together in its own formulation.
How to read eye-health studies
Read the study in context
Check the tested formula, daily dose and participants. Look at which outcomes improved and which did not; measured changes and reported symptoms can tell different stories.
Follow the Haro Clear label
Take one capsule morning and evening with meals. Review the full label with your healthcare professional before starting if you take medication, supplements or have a medical condition.
Know when to seek eye care
A sudden increase in floaters, flashes of light, or a curtain or shadow across your vision needs urgent assessment. Contact an eye doctor or go to an emergency department right away.
Study follow-up periods
The fruit-enzyme trial followed participants for three months; the FLIES trial followed participants for six months. These are the follow-up periods for those study formulas, rather than a predicted timeline for Haro Clear. Individual experiences vary, and some people may not notice a change.
Haro Clear is a dietary supplement and is not intended to diagnose, treat, cure or prevent any disease.
About our processResearch transparency
We cite the sources behind our study explanations and identify the tested ingredients, doses, populations and findings. Results apply to the formulas and people studied; they do not establish equivalent results for Haro Clear.
Disclosure: Haro Health owns and sells Haro Clear.
We review affected content when the label, source information or evidence changes. To flag an error, email hello@harohealth.com with the page link and the wording you want us to check. Please do not send private medical records.
Review status: Updated study explanations are under review. Previously recorded review: September 13, 2026.
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