Research & Evidence
Floater-focused research. Broader daily eye nutrition.
Explore research on eye floaters, retinal carotenoids, macular pigment, and tear-film measures related to dry eye and screen use. See the evidence ↓Our approach
Built around floater research.
Broadened for daily eye nutrition.
Haro Clear combines five nutrient categories represented in
FLIES
Floater Intervention Study (FLIES): a 2021 trial of a five-nutrient supplement for adults with symptomatic vitreous floaters.
, 900 mg of fruit enzymes per daily serving, and the retinal carotenoids lutein and zeaxanthin.
Retinal carotenoids
8mglutein + zeaxanthin
Carotenoids found in the retina and lens, included in every daily Haro Clear serving.
Daily enzyme serving
900mgbromelain + papain
The largest ingredients in the formula by weight.
FLIES Floater Intervention Study (FLIES): a 2021 trial of a five-nutrient supplement for adults with symptomatic vitreous floaters. connection
Five targeted micronutrients.
Broader eye nutrition
9complementary ingredients
Enzymes, carotenoids and targeted micronutrients in one routine.AREDS2 study: supplements for age-related macular degeneration
The Age-Related Eye Disease Study 2 (AREDS2) examined changes to a high-dose supplement formula for people at risk of advanced age-related macular degeneration (AMD).
- Lutein
- Zeaxanthin
- Vitamin C
- Zinc
Haro Clear uses different amounts and combines these with five ingredients that are not part of the standard AREDS2 formula.
What was tested?
The NEI-funded trial enrolled 4,203 adults with intermediate AMD in both eyes, or intermediate AMD in one eye and advanced AMD in the other. Researchers tested adding lutein and zeaxanthin or omega-3 fatty acids, removing beta-carotene, and lowering zinc in the original AREDS formula. They measured progression to advanced AMD over about five years.
How to read the findings
In the main analysis, adding lutein and zeaxanthin or omega-3s did not significantly reduce progression to advanced AMD. Further analyses supported using lutein and zeaxanthin in place of beta-carotene. AREDS/AREDS2 evidence supports specific supplement formulas for certain stages of AMD.
Ask your eye-care professional whether an AREDS2 formula is appropriate for your AMD stage, and discuss other medicines and supplements you take.
What is in the standard AREDS2 formula?
| Nutrient | Daily amount |
|---|---|
| Vitamin C | 500 mg |
| Vitamin E | 400 IU |
| Zinc | 80 mg |
| Copper | 2 mg |
| Lutein | 10 mg |
| Zeaxanthin | 2 mg |
The standard formula contains no beta-carotene. AREDS2 also studied 25 mg zinc. See the NEI formula guidance.
Does AREDS2 help with eye floaters?
AREDS2 studied AMD progression, not eye-floater symptoms. Its findings do not establish that AREDS2 supplements treat floaters.
Is Haro Clear an AREDS2 supplement?
No. Haro Clear has different amounts and does not contain vitamin E or copper. View Haro Clear’s ingredients and daily amounts.
Explore macular degeneration research
- National Eye Institute: AREDS2 formula and clinical guidance
- Read the complete study Age-Related Eye Disease Study 2 Research Group (2013) · JAMA · 309(19):2005–2015 · DOI: 10.1001/jama.2013.4997
About our processResearch transparency
We cite the sources behind our study explanations and identify the tested ingredients, doses, populations and findings. Results apply to the formulas and people studied; they do not establish equivalent results for Haro Clear.
Disclosure: Haro Health owns and sells Haro Clear.
We review affected content when the label, source information or evidence changes. To flag an error, email hello@harohealth.com with the page link and the wording you want us to check. Please do not send private medical records.
Review status: Updated study explanations are under review. Previously recorded review: September 13, 2026.
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